Proniosomal gel for transdermal delivery of lornoxicam: optimization using factorial design and in vivo evaluation in rats
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چکیده
منابع مشابه
Tolterodine Tartrate Proniosomal Gel Transdermal Delivery for Overactive Bladder
The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation. Formulations were analyzed for drug entrapment efficiency (EE), vesicle size, surface morphology...
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The main aim of the study was to develop and statistically optimize the proniosomal gel for enhanced transdermal delivery using 3(2) factorial designs to investigate the influence of both non-ionic surfactant and cholesterol to maximize the entrapment efficiency and flux. The concentration of non-ionic surfactant and cholesterol were taken as independent variables, while entrapment efficiency a...
متن کاملNovel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 2(3) factorial design and in vivo evaluation in rabbits.
CONTEXT Proniosomes offer a versatile vesicle drug delivery concept with potential for delivery of drugs via transdermal route. OBJECTIVES To develop proniosomal gel using cremophor RH 40 as non-ionic surfactant containing the antihypertensive drug lacidipine for transdermal delivery so as to avoid its extensive first pass metabolism and to improve its permeation through the skin. MATERIALS...
متن کاملIn vitro and in vivo evaluation of a novel testosterone transdermal delivery system (TTDS) using palm oil base
Objective (s): Transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. A novel testosterone transdermal delivery system (TDDS) was developed using a palm oil base called HAMINTM (a commercial product) and tested using in vitro and in vi...
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ژورنال
عنوان ژورنال: DARU Journal of Pharmaceutical Sciences
سال: 2019
ISSN: 2008-2231
DOI: 10.1007/s40199-019-00242-x